David Sinclair: Harvard geneticist and anti-ageing pioneer

Is it possible to cheat ageing? Harvard professor David Sinclair believes yes. He is one of the leading minds in ageing research and describes ageing itself as a treatable process - a radical idea that gives hope to millions of people. In this detailed portrait, you will find out who David Sinclair is, what scientific breakthroughs he has achieved and what you can personally take away from his findings on longevity and health. From the lab at Harvard Medical School to Sinclair's own daily habits, immerse yourself in the world of a man who is redefining the boundaries of ageing.

Who is David Sinclair?

David A. Sinclair is an Australian-born biologist and Professor of Genetics at Harvard Medical School. He became known as a pioneer in longevity research and as co-director of the Paul F. Glenn Center for Biology of Aging Research. Early on in his career, Sinclair challenged conventional views on ageing. In 1997, when he was only 28 years old, he published a groundbreaking study in the journal Cell in which he showed that certain DNA circles accumulate in ageing yeast cells, which presumably drives the ageing process of the cell[6][7]. This discovery of extrachromosomal rDNA circles immediately made Sinclair famous among experts and laid the foundation for his lifelong research topic - the biological causes of ageing.

In the following years, Sinclair worked in Leonard Guarente's laboratory at MIT and later independently at Harvard. His goal: to find out why we age and to develop strategies to slow down or even reverse the ageing process. His approach is provocative. For Sinclair, ageing is not an inevitable fact, but a "loss of information" in the body that can potentially be repaired. This mindset - ageing as a treatable disease - made him the pioneer of a new generation of scientists who want to influence ageing processes in a targeted manner. Today, David Sinclair is considered one of the most influential age researchers in the world. He has been voted one of the "100 Most Influential People" by Time Magazine several times and has received numerous awards for his work. Let's take a look at the scientific milestones Sinclair has achieved - and what they mean.

Breakthrough in research: longevity genes and resveratrol

David Sinclair achieved one of his biggest breakthroughs in the early 2000s. At that time, he and his colleagues discovered special genes that influence lifespan: sirtuins. Sirtuins are enzymes that are involved in gene regulation and lose activity with age. Sinclair discovered that activating the sirtuin gene SIR2 extends the lifespan of yeast cells. Shortly afterwards, his team showed that a natural molecule called resveratrol can activate sirtuins and thus drastically extend the life of simple organisms. Resveratrol is a polyphenol known from red grapes. In a high-profile study in 2003, Sinclair reported that resveratrol increased the lifespan of baker's yeast by up to 70%(8,9) - a spectacular result that suggested that natural ingredients can influence ageing processes (not yet confirmed by EFSA; further studies required).

Research continued apace: in 2004, Sinclair, in collaboration with others, was able to show that resveratrol also works in more complex organisms. In experiments with threadworms and fruit flies, the molecule also prolonged life - but only if the corresponding sirtuin genes were intact(10,11). This study in Nature 2004 proved that sirtuin activators such as resveratrol can slow down the ageing process in various living organisms (at least under laboratory conditions)(12,13). The scientific community was electrified: For the first time, there was concrete evidence that so-called "calorie restriction mimetics" - substances that mimic the effects of diet and fasting - could influence ageing. Many media outlets promptly dubbed resveratrol the "fountain of youth in a bottle of wine".

The next step towards application followed in 2006. Sinclair's team tested resveratrol on mammals. In a pioneering study, mice on a high-fat diet were given high doses of resveratrol. The result: although the mice continued to eat unhealthily, the animals treated with resveratrol lived significantly healthier and longer than the untreated controls(14,15). In particular, their risk of age-associated diseases decreased; the resveratrol mice remained physically more active into old age and showed improved liver values. The researchers concluded that resveratrol mimics some effects of diet and partially offsets the damage of a high-fat diet (Not yet confirmed by EFSA; further studies needed). This finding, published in Nature in 2006, made headlines around the world. It demonstrated for the first time that a small molecule can extend the health span of mammals - a milestone in ageing research.

The excitement surrounding resveratrol led to Sinclair co-founding a biotech company called Sirtris in 2008 to develop sirtuin activators as drugs. The pharmaceutical company GlaxoSmithKline (GSK) paid an impressive 720 million US dollars to take over Sirtris - an indicator of the great potential attributed to Sinclair's approach. However, the further development of resveratrol-based drugs was more difficult than hoped. Later experiments showed, for example, that resveratrol alone did not prolong the lives of mice on a normal diet unless they were on a high-fat diet. In other words, the life-extension effect could not be reproduced in all contexts - which warned researchers to be cautious. Nevertheless, resveratrol remains a highly interesting molecule: Resveratrol derivatives with better bioavailability are now being researched, and its ability to positively influence cell mechanisms such as inflammation and metabolism is well documented. Sinclair himself still takes 1 gram of resveratrol daily (stirred into yoghurt) and is convinced of its health benefits - although he emphasizes that it is not a miracle cure and does not replace a healthy lifestyle.

NAD+, cell energy and the epigenetic clock: ageing at the molecular level

Following the resveratrol successes, Sinclair shifted his focus to another key factor in ageing: the molecule NAD+ (nicotinamide adenine dinucleotide). NAD+ is a coenzyme that is involved in hundreds of metabolic processes - including the function of sirtuins. The NAD+ level in our cells decreases with age. Sinclair suspected that the loss of NAD+ could be a driver of ageing. In 2013, he provided convincing evidence of this: his working group showed in Cell that older mice exhibit a significant drop in NAD+, which leads to a kind of "pseudo-hypoxia" in the cells - communication between the cell nucleus and mitochondria (the cell's power plants) breaks down. Interestingly, the researchers succeeded in reversing this process: If old mice were given a precursor of NAD+ (the molecule NMN), the NAD+ levels rose again and the mitochondria suddenly functioned as they did in young cells. In Sinclair's experiment, two-year-old mice had physiological levels like six-month-old animals after just one week of treatment with the NAD booster - an astonishing rejuvenation effect (not yet confirmed by EFSA; further studies required).

These results, published at the end of 2013, caused a huge stir among experts. They support the idea that ageing at the cellular level is characterized by declining energy and signalling processes - and that this decline can be specifically slowed down. NAD+ plays a central role in this. Since then, Sinclair has added NAD+ precursors such as NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) to his personal prevention program. These substances are considered promising dietary supplements for maintaining cellular energy production in old age. Initial clinical studies on humans are cautiously optimistic. For example, a trial in overweight middle-aged women published in Science in 2021 showed an improvement in muscle function and sugar metabolism after ten weeks of NMN administration(18,19). Although these are only the first steps, they raise the hope that we will one day be able to pharmacologically combat the signs of ageing.

Sinclair's most important theoretical contribution to biogerontology is his information theory of ageing. Put simply, he sees ageing as the result of "lost epigenetic information". In the course of life, DNA is damaged (for example by radiation or oxidative stress). Although the cells repair the breaks, the epigenetic programming gets mixed up in the process - genes are switched on or off even though they shouldn't be. Sinclair compares this to scratches on a CD: the digital music (DNA code) remains the same, but the playback becomes faulty because scratches (epigenetic disturbances) disrupt the information. He was able to impressively substantiate this hypothesis in 2023: In a sensational study in Cell (Jan. 2023), his team induced accelerated DNA damage in young mice - and the animals aged biologically in fast motion. The researchers then "injected" an epigenetic backup: Using gene therapy interventions, they reset certain epigenetic markers. The result: the mice rejuvenated and regained lost fitness. In other words, ageing could be specifically accelerated and reversed in this model (not yet confirmed by EFSA; further studies required). This work supports the thesis that it is not irreparable mutations that drive ageing, but reversible epigenetic changes - a paradigm shift in the understanding of ageing(20,21).

In 2020, Sinclair had already shown that epigenetic reprogramming can cure specific age-related ailments. He used the so-called Yamanaka factors - normally a set of four genes that can revert cells into embryonic stem cells. Sinclair modified the method slightly (three factors were enough to prevent cancer risks) and introduced them specifically into the eyes of old mice. The result was sensational: the old mice with vision problems regained their sight because the retinal cells were rejuvenated. In Nature 2020, Sinclair and colleagues reported that they had successfully turned back the "epigenetic age switch" in the eye. The treatment cured both age-related optic nerve damage and an eye condition caused by glaucoma. In practical terms, this meant that a typical sign of ageing was reversed for the first time ever (not yet confirmed by EFSA; further studies required). These findings raised hopes that similar rejuvenation strategies could be developed for other organs. Sinclair himself spoke of a "proof of concept" that ageing in tissue is not permanent. His vision: one day we could use gene therapy or drugs to "reset" entire organs or even the entire body in order to cure diseases of old age.

Of course, such applications in humans are still in their infancy. But Sinclair's work is pushing the boundaries of what is scientifically conceivable. Where age used to be seen as an unchangeable fate, researchers now see real possibilities for intervention. Sinclair always emphasizes that lifestyle factors and prevention must go hand in hand with high-tech therapies. This is where his personal strategies come into play.

Sinclair's anti-ageing lifestyle: what does he do himself?

David Sinclair is not only active in the laboratory - he is also trying to slow down the ageing process in himself. His motto is: "Genetic predisposition loads the gun, but lifestyle pulls the trigger." Let's take a look at the specific measures Sinclair integrates into his everyday life and what the science says about them:

• Intermittent fasting: Sinclair regularly skips meals and practices daily window fasting (e.g. fast for 16 hours, eat for 8 hours). He often skips breakfast so that he only eats a late lunch and dinner. Why? Fasting puts the body under mild stress, which stimulates repair processes (autophagy) and reduces inflammation. Studies support these benefits: Intermittent fasting can extend lifespan in animals and improve numerous health markers in humans(24,25) - for example, positive effects on body weight, blood sugar, blood pressure and inflammation levels have been observed. In the XTRAFUEL article on intermittent fasting, you can read why controlled breaks between meals are good for the metabolism. There is also evidence that fasting activates similar molecular pathways as resveratrol or diet (e.g. sirtuins and AMP kinase are activated). Sinclair reports that fasting makes him feel more energetic and has improved his "youthfulness" marker - the epigenetic clock. Of course, this varies from person to person. The important thing is: fasting should always fit in with your lifestyle and not cause malnutrition. (Note: The health effects of fasting are the subject of current research; according to EFSA, a general health-related statement has not been confirmed and further studies are required).
• Plant-based diet and less meat: Sinclair avoids excessive consumption of animal products and instead focuses on vegetables, salads, legumes and occasionally fish. A colorful, predominantly plant-based diet provides many polyphenols and antioxidants that can protect cells from damage. Resveratrol is just one example - Sinclair is also investigating other plant-based bioactive substances (e.g. quercetin from onions or EGCG from green tea) for potential life-prolonging effects. The science here is still ongoing, but epidemiological studies suggest that people with a vegetable-rich diet often live to a healthier age. One thing is certain: fruit and vegetables in line with the current recommendation (five portions a day) provide important vitamins, minerals and phytochemicals. (Not yet confirmed by EFSA; further studies required).
• Regular exercise: Although he is not a competitive athlete, Sinclair makes sure to exercise daily. This usually involves brisk walks, cycling or short strength training sessions using his own body weight. Sport is an underestimated "anti-ageing remedy": physical activity keeps the cardiovascular system young, improves insulin sensitivity and maintains muscle mass - all factors that are associated with a longer health span. Studies also show that moderate endurance and strength training can reduce inflammation and counteract age-related muscle loss. (Although there are no EFSA-compliant health claims for this, the health benefits of exercise are undisputed). Sinclair particularly recommends intensive short bursts of exercise (HIIT) and plenty of everyday movement (climbing stairs, walking) to keep the metabolism on its toes.
• Hunger in moderation, little sugar: The researcher is convinced that a slight calorie deficit and avoiding sugar and highly processed carbohydrates slows down ageing. In fact, calorie restriction activates longevity-promoting signaling pathways in many organisms (such as sirtuins and the mTOR metabolic pathway). Sinclair himself says he never leaves the dinner table completely full and rarely snacks on sweets. High blood sugar levels have been shown to promote inflammation and glycation (the accumulation of sugar on proteins), which can promote ageing processes. Hence his advice: less industrial sugar, more whole foods - a recommendation that traditional nutritional teachings also preach. (This is not a specific health claim, but a general health tip).
• Food supplements with brains: In addition to resveratrol and NMN, which we've already covered above, Sinclair takes other supplements that have been linked to longevity in studies. These include, for example, spermidine (a natural substance in wheat germ and long-ripened cheese that promotes autophagy), fisetin (a plant substance from strawberries that can eliminate ageing cells as a senolytic) as well as omega-3 fatty acids, magnesium and a vitamin B complex. These "basics" are intended to ensure that no deficiencies sabotage health. **Vitamin D**, for example, contributes to the normal function of the immune system and supports the maintenance of normal bones (EFSA-approved health claim). Vitamin D is particularly important in old age, as the body's own synthesis via the skin decreases. Sinclair keeps his vitamin D level in the upper normal range. He always combines it with **vitamin K2**, which contributes to normal blood clotting and the maintenance of normal bones (also EFSA-approved). If you are thinking about taking supplements yourself: quality and dosage are crucial. Pharmacy-quality products - such as the vitamin D3+K2 capsules from XTRAFUEL - offer high-purity active ingredients in a sensible dosage. Nevertheless: consult a doctor and do not imitate everything uncritically. Sinclair's personal protocol is scientifically based, but individual needs may vary.
• Metformin & Co.: anti-ageing drugs? It is remarkable that David Sinclair also uses drugs that were actually developed for other purposes. For example, he takes **Metformin** - a proven diabetes medication that is said to have interesting anti-ageing effects in studies. In mouse experiments, low doses of metformin extended the lifespan and improved the fitness of the animals(26,27). In addition, in some analyses, type 2 diabetics taking metformin live longer than metabolically healthy people without diabetes(28,29) (not yet confirmed by EFSA; further studies required). Among other things, metformin works by activating the energy sensor AMPK - a signaling pathway that also plays a role in fasting - and reduces oxidative stress and inflammation. However, metformin can have side effects (especially in the gastrointestinal tract) and requires a prescription - it should definitely not be used for self-medication without medical advice! In addition to Metformin, Sinclair occasionally experiments with **Rapamycin** (an immunosuppressant that can extend the lifespan of animals at low doses) and takes a small daily dose of **Aspirin**. Such substances belong to the "off-label" category in anti-ageing and the data situation is not yet clear. However, they show how far Sinclair is prepared to go in order to possibly gain a few healthy years. For most of us, caution is advised until human studies show a clear risk-benefit profile.
• Sleep, cold and other biohacks: Sinclair repeatedly emphasizes how important **sleep** is for regeneration and healthy aging. Seven to eight hours a night is ideal for most people. He pays attention to sleep hygiene, darkens his bedroom completely and occasionally uses melatonin to support his biorhythm. He also relies on **hormesis** - small, controlled stress stimuli. These include exposure to cold (cold showers, ice baths) and heat (regular sauna sessions). These stimuli activate repair mechanisms in the body and, according to Sinclair, strengthen the cells' resistance. Studies confirm that frequent sauna use is associated with lower mortality(30,31) and cold applications can reduce inflammation markers. (Not yet confirmed by the EFSA; further studies required.) For Sinclair, **mental fitness** is also part of this: He recommends curiosity, lifelong learning and social activities - because the brain and social connectedness contribute a lot to overall health in old age.

The mix of all these measures - high-tech supplements, classic lifestyle factors and a curious mind - is what makes David Sinclair's approach so inspiring. In a way, he himself is a test subject in his research laboratory and already exemplifies much of what science considers beneficial. Of course, he always points out that there are no guarantees. But the combination of solid evidence and his own experimental spirit is what sets Sinclair apart.

Criticism and unanswered questions

Despite all the enthusiasm for Sinclair's work, it is important to maintain a balanced view. There are certainly voices in the scientific community that urge caution. Some of his theories - such as that ageing is primarily driven by epigenetic changes - are not yet generally accepted. Other researchers emphasize that genetic damage, the shortening of telomeres or cellular senescence (ageing of individual cells) also play a central role. Sinclair himself has also been criticized for provocative statements ("Aging is a disease") because some fear that this raises false hopes of a kind of immortality. The fact is: so far, no approach has been able to significantly extend the maximum human lifespan beyond the natural limit. We do not know whether the rejuvenation effects achieved in animals are fully transferable to humans.

Another point of criticism is that some of Sinclair's early findings were controversial. For example, there were studies that relativized the initially reported benefits of resveratrol or found no effect of sirtuin activation on lifespan(32,33). The marketing of "anti-ageing pills" has also been criticized. In 2008 - after the hype surrounding resveratrol - it turned out, for example, that a substance promoted by Sinclair's companies (SRT1720) was ultimately not as effective as hoped; GSK later stopped development. However, such setbacks are normal in the research process. Sinclair always openly emphasizes that science continues to develop and that mistakes need to be corrected. His lesson from this is that more human studies are needed before definitive statements can be made (hence his commitment to initiating large clinical studies such as the TAME metformin study).

Despite some criticism, it remains undisputed that David Sinclair has given enormous impetus to ageing research. He has made topics socially acceptable that were still considered science fiction 20 years ago. Thanks to him and others, we now know a great deal more about the molecular mechanisms of ageing. Discourse and healthy skepticism are part and parcel of science. Sinclair himself says that he welcomes criticism because it helps to ask the right questions for future studies. The big question remains: Will one of his approaches be therapeutically useful in humans at some point? The next 10-20 years of research - many studies are already underway - will provide clearer answers.

Conclusion: inspiration for a longer, healthier life

David Sinclair's work and lifestyle impressively demonstrate that ageing is not a purely passive process. To a certain extent, we have control over how healthy we grow old. Of course, there is no magic pill (yet) and no guarantees, but Sinclair's research results provide tangible evidence of what we can do:

• Keep your lifestyle "cell-friendly": make sure you eat a healthy diet (lots of plants, moderate calories, low sugar), exercise regularly and get enough sleep. This forms the basis for healthy ageing.
• Use positive stress stimuli: Whether it's intermittent fasting, cold baths or saunas (if they are safe for your health) - these small stressors activate the body's own repair mechanisms and can be good for your cells.
• Stay curious and socially active: Mental and social health are important pillars of longevity. Learn new things, cultivate friendships and keep your brain active - this will keep you young at heart.
• Find out about useful supplements: substances such as vitamin D3, K2, omega-3 or certain plant extracts have proven health benefits and can be used in a targeted manner (always in consultation with specialists). More experimental substances such as NAD boosters or spermidine are promising, but the data here is still being developed - follow the research and decide together with a doctor whether this is an option for you.
• Be patient and remain realistic: we won't be able to stop ageing completely any time soon. It's about maximizing the healthy years. Progress happens gradually. It is important to take care of your health now so that you can benefit from future anti-ageing developments. A 90-year-old in good health will ultimately benefit more from a new therapy than a 90-year-old with a lot of previous damage - so start investing in your "future self" early.

David Sinclair serves as an inspiration for many to take responsibility for their own ageing. He combines scientific excellence with practical tips and personal example. Not everyone will want to implement his rather strict regime 1:1 - and you don't have to. But certain principles can be easily integrated: for example, skipping dinner once or twice a week, taking a walk every day, adding colorful vegetables to your plate, supplementing vitamin D in winter or leaving your comfort zone every now and then (keyword cold showers 🥶). Such small steps can make a big difference in the long term. And who knows - if Sinclair's bold visions come true, we could actually live much longer healthy lives in the future. Until then: stay healthy, stay curious!

David Sinclair shows us what could be possible. His motto "ageing is optional" may still sound exaggerated today, but it is inspiring researchers around the world to push boundaries. For us personally, it is already worth learning from his findings and consciously investing in our own extra life (XTRAFUEL 😉). With this in mind, here's to a long, fulfilling and healthy life!

Frequently asked questions (FAQ) about David Sinclair & longevity

How old is David Sinclair and what is his biological age?

David Sinclair was born in Australia in 1969. He is now in his mid-50s (as of 2025). Despite his chronological age, Sinclair claims to be much younger biologically. He regularly measures his so-called epigenetic clock - i.e. biological age markers in his cells. In interviews, he has mentioned that his biological age is over ten years younger than his actual age. This means that his cells show characteristics that you would expect to see in someone in their early 40s(34). Of course, such a measurement is not perfect and is subject to debate, but Sinclair sees it as evidence that a healthy lifestyle and possibly his supplements have slowed down his ageing. The fact is: Sinclair looks mentally and physically very fit for his age. He himself occasionally jokes that he would be disappointed if he only reached the average human age - he is aiming for over 100 years, in the best possible health.

Has David Sinclair written a book or a podcast?

Yes, Sinclair also shares his knowledge outside the professional world. In 2019, he published the popular science book "Lifespan: Why We Age - and Why We Don't Have To ". In it, he explains his theory of ageing in detail and gives tips on how everyone can influence their lifespan. The book became a New York Times bestseller and has been well received around the world. Sinclair has also been hosting his own podcast called "Lifespan" since 2022. In the podcast series (one season with several episodes so far), he and co-hosts discuss various aspects of ageing and longevity - from nutrition to medication to genetics. The podcast is available for free and offers a good introduction to Sinclair's way of thinking for non-experts. So if you prefer to listen rather than read, you can get to know many of his ideas in an understandable way.

What supplements does David Sinclair take every day?

Sinclair's daily "stack" of supplements has almost cult status in the scene - he is often asked what exactly he takes. According to his own statements (e.g. in podcasts and interviews), he takes supplements every day:

• Resveratrol: about 1 gram, in the morning, usually stirred into yogurt (for better absorption). This is a plant polyphenol known from grapes - Sinclair hopes to achieve sirtuin-activating effects with it. (Note: this dose is very high; normal resveratrol capsules often only contain 100-250 mg).
• NMN (nicotinamide mononucleotide): approx. 1 gram per day. NMN is an NAD+ precursor. He takes it in pill or powder form to boost his NAD levels. (NMN is currently not freely available as a food supplement in the EU, see next question).
• Vitamin D3 + K2: for the immune system and bones. He keeps his vitamin D level in the upper normal range.
• Vitamin B complex: B vitamins are involved in many metabolic processes. Sinclair wants to ensure that there is no B deficiency.
• Omega-3 fatty acids: for example fish oil or algae oil capsules for cardiovascular health and anti-inflammation.
• Magnesium: for muscles, nerves and many enzymatic reactions.
• Spermidine: occasionally, as it promotes autophagy processes (he partly consumes spermidine-rich foods such as soybeans or food supplements).
• Fisetin: as a cure, a plant substance that can kill off senescent cells in studies (senolytic effect).

In addition to these supplements, Sinclair also uses medication (metformin, occasionally rapamycin, daily low-dose aspirin). But here he warns that this is not a recommendation for the general public - he makes these decisions based on personal risk assessment and in consultation with doctors. Every person is different, so supplementation and medication should always be discussed individually with a doctor.

Can I buy the substances promoted by Sinclair, such as NMN or metformin, myself?

Caution is advised here. **Metformin** requires a prescription and is only approved for diabetics - it would be illegal (and potentially dangerous) to take it without medical advice. **NMN**, on the other hand, is not currently approved as a food supplement in the EU (as of 2025). The European Food Safety Authority classifies NMN as a so-called novel food, for which no approval has yet been granted. Accordingly, reputable suppliers are not allowed to sell it freely. In the USA, NMN was available as a supplement until recently, but the FDA has announced that it may classify NMN as a drug (because it is under review as a drug) - this could also stop OTC sales there. **Nicotinamide riboside (NR)** - another NAD precursor - is however permitted in some countries (including the EU) in certain doses as a dietary supplement. Sinclair himself obtains some of his NMN from special sources (previously from his company). Consumers should stay away from unauthorized substances. If you are interested in NAD boosting, NR would be a legal alternative, although the long-term effects in humans are still being researched.

What do other scientists say about Sinclair's theories?

Many colleagues respect Sinclair for his pioneering work, but there is also criticism and differing views. Some researchers emphasize that aging is an extremely complex process and doubt that it can be reduced to one main factor (like Sinclair's "loss of information"). For example, there are debates about how important DNA mutations and telomere shortening are compared to epigenetic changes. Some people are critical of the idea propagated by Sinclair of viewing ageing as a disease - they fear that this would raise exaggerated expectations among the public. There has also been scientific controversy: not all studies have been able to confirm Sinclair's earlier findings. In 2011, a study by Burnett et al. showed that additional copies of the Sir2 gene in certain model organisms did not prolong life(35,36), contrary to earlier reports. There have also been mixed results around resveratrol - in some studies on healthy mice, it did not confer a lifespan benefit. However, such discussions are normal in science. Overall, the consensus is that Sinclair has made extremely valuable contributions, even if not every aspect of his approach is uncontroversial. It is precisely discourse that drives research forward. Sinclair himself welcomes constructive criticism and believes that it helps to design better studies.

What does David Sinclair's everyday life look like - does he live an extremely ascetic life?

You might assume that someone like Sinclair is constantly in the lab and otherwise only diets - but it's not that drastic. His everyday life is very similar to that of a busy professor. According to interviews, he gets up relatively early in the morning. He often just has a coffee and skips breakfast (part of his intermittent fasting). He drives or walks to work (Harvard Medical School in Boston), where he conducts research and teaching. At lunchtime, he usually eats something light, such as a salad with protein, and takes his supplements. In the afternoon or evening, he tries to find time for exercise - be it a walk with the dog, cycling home or a short strength training session two or three times a week. He eats dinner with his family, sometimes indulging in fish or meat, but mainly plant-based. Sinclair drinks little to no alcohol. He emphasizes that even moderate alcohol consumption is not good for the body - ironically, he gets resveratrol from grapes, but hardly ever drinks wine. In fact, you would have to drink hundreds of glasses of red wine to get 1 g of resveratrol (which of course would be nonsensical and harmful to your health). Sinclair prefers to go to bed early, ideally before 11pm, to get his ~7 hours of sleep. Overall, he lives a disciplined life, but not in a completely off-the-wall extreme mode. He himself says that you should enjoy life despite biohacking and not just count calories - he loves dark chocolate in moderation and good company, for example. His motto: find the right habits, but don't forget to live life.

Does David Sinclair want to become immortal?

Sinclair usually waves this question away. He is not looking for immortality in the science fiction sense. Rather, his aim is to make the "chronic ailment of old age" treatable and to significantly extend the time we can spend healthy and active. He often speaks of the "healthspan", which he wants to maximize - even if the maximum human lifespan (longevity beyond 120 years) may have a hard biological limit. Sinclair once said that he found it unacceptable that so many people have to suffer from old-age ailments for so many years; if ageing could be delayed, we would get diseases such as Alzheimer's, heart failure or diabetes much later or not at all. He is therefore concerned with the quality of life years at least as much as the quantity. At the same time, he is optimistic that people could well live to be 100 or 120 years old in the future, provided they are in good health. "Ageing is optional" - by this he does not mean that we become immortal, but that we learn to understand and influence the biological mechanisms of ageing. It remains to be seen whether he himself will live to be 100 or older - but he is doing a lot to achieve this. And if science makes it possible, Sinclair would certainly be one of the first to try out new anti-ageing therapies.

Sources

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